diff --git a/pkgs/development/python-modules/aplpy/default.nix b/pkgs/development/python-modules/aplpy/default.nix
index 0304a8eff852..14141cf72d36 100644
--- a/pkgs/development/python-modules/aplpy/default.nix
+++ b/pkgs/development/python-modules/aplpy/default.nix
@@ -32,6 +32,20 @@ buildPythonPackage rec {
     hash = "sha256-KCdmBwQWt7IfHsjq7pWlbSISEpfQZDyt+SQSTDaUCV4=";
   };
 
+  # Fix build with Astropy 6 and Python 3.12.
+  patches = [
+    # https://github.com/aplpy/aplpy/pull/496
+    (fetchpatch {
+      url = "https://github.com/aplpy/aplpy/commit/d232a4984bc6a83ec86dfdc3ab3bc1b05de44c48.patch";
+      hash = "sha256-jGUTzIrVdGNPy0BV8w46jzz045fDXBisiwIn90bn7oY=";
+    })
+    # https://github.com/aplpy/aplpy/pull/497
+    (fetchpatch {
+      url = "https://github.com/aplpy/aplpy/commit/468be394970b39f1aaa6debef51eb674e2dd86d8.patch";
+      hash = "sha256-/ovLrFOKb3RQ8TZSviuOV6EYNgz0gtrhVWZLFJBrzFg=";
+    })
+  ];
+
   nativeBuildInputs = [
     setuptools
     setuptools-scm