diff --git a/pkgs/applications/science/biology/MACS2/default.nix b/pkgs/applications/science/biology/MACS2/default.nix
index cc398608ce52..868479c48e55 100644
--- a/pkgs/applications/science/biology/MACS2/default.nix
+++ b/pkgs/applications/science/biology/MACS2/default.nix
@@ -9,6 +9,12 @@ python3.pkgs.buildPythonPackage rec {
     sha256 = "1rcxj943kgzs746f5jrb72x1cp4v50rk3qmad0m99a02vndscb5d";
   };
 
+  postPatch = ''
+    # remove version check which breaks on 3.10
+    substituteInPlace setup.py \
+      --replace 'if float(sys.version[:3])<3.6:' 'if False:'
+  '';
+
   propagatedBuildInputs = with python3.pkgs; [ numpy ];
 
   # To prevent ERROR: diffpeak_cmd (unittest.loader._FailedTest) for obsolete
@@ -21,5 +27,7 @@ python3.pkgs.buildPythonPackage rec {
     license = licenses.bsd3;
     maintainers = with maintainers; [ gschwartz ];
     platforms = platforms.linux;
+    # error: ‘PyThreadState’ {aka ‘struct _ts’} has no member named ‘use_tracing’; did you mean ‘tracing’?
+    broken = true;
   };
 }