diff --git a/pkgs/development/libraries/webkitgtk/default.nix b/pkgs/development/libraries/webkitgtk/default.nix
index 7ca5ffc19020..07fc616efacc 100644
--- a/pkgs/development/libraries/webkitgtk/default.nix
+++ b/pkgs/development/libraries/webkitgtk/default.nix
@@ -20,8 +20,6 @@
 , wayland
 , wayland-protocols
 , libwebp
-, libwpe
-, libwpe-fdo
 , enchant2
 , xorg
 , libxkbcommon
@@ -48,7 +46,6 @@
 , libintl
 , lcms2
 , libmanette
-, openjpeg
 , geoclue2
 , sqlite
 , gst-plugins-base
@@ -56,6 +53,7 @@
 , woff2
 , bubblewrap
 , libseccomp
+, libbacktrace
 , systemd
 , xdg-dbus-proxy
 , substituteAll
@@ -70,7 +68,7 @@
 
 stdenv.mkDerivation (finalAttrs: {
   pname = "webkitgtk";
-  version = "2.42.5";
+  version = "2.44.0";
   name = "${finalAttrs.pname}-${finalAttrs.version}+abi=${if lib.versionAtLeast gtk3.version "4.0" then "6.0" else "4.${if lib.versions.major libsoup.version == "2" then "0" else "1"}"}";
 
   outputs = [ "out" "dev" "devdoc" ];
@@ -81,7 +79,7 @@ stdenv.mkDerivation (finalAttrs: {
 
   src = fetchurl {
     url = "https://webkitgtk.org/releases/webkitgtk-${finalAttrs.version}.tar.xz";
-    hash = "sha256-tkJ4wfILjP2/tf9XPDfYcaunSh2ybZs5906JU/5h50k=";
+    hash = "sha256-xmUw5Bulmx7bpO6J7yCyGI4nO+0El+lQhHKePPvjDIc=";
   };
 
   patches = lib.optionals stdenv.isLinux [
@@ -90,13 +88,6 @@ stdenv.mkDerivation (finalAttrs: {
       inherit (builtins) storeDir;
       inherit (addOpenGLRunpath) driverLink;
     })
-
-    # Hardcode path to WPE backend
-    # https://github.com/NixOS/nixpkgs/issues/110468
-    (substituteAll {
-      src = ./fdo-backend-path.patch;
-      wpebackend_fdo = libwpe-fdo;
-    })
   ];
 
   preConfigure = lib.optionalString (stdenv.hostPlatform != stdenv.buildPlatform) ''
@@ -150,17 +141,12 @@ stdenv.mkDerivation (finalAttrs: {
     libxkbcommon
     libxml2
     libxslt
+    libbacktrace
     nettle
-    openjpeg
     p11-kit
     sqlite
     woff2
-  ] ++ (with xorg; [
-    libXdamage
-    libXdmcp
-    libXt
-    libXtst
-  ]) ++ lib.optionals stdenv.isDarwin [
+  ] ++ lib.optionals stdenv.isDarwin [
     libedit
     readline
   ] ++ lib.optional (stdenv.isDarwin && !stdenv.isAarch64) (
@@ -175,8 +161,7 @@ stdenv.mkDerivation (finalAttrs: {
     libseccomp
     libmanette
     wayland
-    libwpe
-    libwpe-fdo
+    xorg.libX11
   ] ++ lib.optionals systemdSupport [
     systemd
   ] ++ lib.optionals enableGeoLocation [
@@ -184,7 +169,6 @@ stdenv.mkDerivation (finalAttrs: {
   ] ++ lib.optionals withLibsecret [
     libsecret
   ] ++ lib.optionals (lib.versionAtLeast gtk3.version "4.0") [
-    xorg.libXcomposite
     wayland-protocols
   ];
 
@@ -214,8 +198,8 @@ stdenv.mkDerivation (finalAttrs: {
     "-DENABLE_X11_TARGET=OFF"
     "-DUSE_APPLE_ICU=OFF"
     "-DUSE_OPENGL_OR_ES=OFF"
-  ] ++ lib.optionals (lib.versionAtLeast gtk3.version "4.0") [
-    "-DUSE_GTK4=ON"
+  ] ++ lib.optionals (lib.versionOlder gtk3.version "4.0") [
+    "-DUSE_GTK4=OFF"
   ] ++ lib.optionals (!systemdSupport) [
     "-DENABLE_JOURNALD_LOG=OFF"
   ];
diff --git a/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch b/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch
deleted file mode 100644
index 48e7d9cca745..000000000000
--- a/pkgs/development/libraries/webkitgtk/fdo-backend-path.patch
+++ /dev/null
@@ -1,11 +0,0 @@
---- a/Source/WebKit/UIProcess/glib/WebProcessPoolGLib.cpp
-+++ b/Source/WebKit/UIProcess/glib/WebProcessPoolGLib.cpp
-@@ -84,7 +84,7 @@ void WebProcessPool::platformInitializeWebProcess(const WebProcessProxy& process
- 
- #if PLATFORM(WAYLAND)
-     if (WebCore::PlatformDisplay::sharedDisplay().type() == WebCore::PlatformDisplay::Type::Wayland && parameters.dmaBufRendererBufferMode.isEmpty()) {
--        wpe_loader_init("libWPEBackend-fdo-1.0.so.1");
-+        wpe_loader_init("@wpebackend_fdo@/lib/libWPEBackend-fdo-1.0.so.1");
-         if (AcceleratedBackingStoreWayland::checkRequirements()) {
-             parameters.hostClientFileDescriptor = UnixFileDescriptor { wpe_renderer_host_create_client(), UnixFileDescriptor::Adopt };
-             parameters.implementationLibraryName = FileSystem::fileSystemRepresentation(String::fromLatin1(wpe_loader_get_loaded_implementation_library_name()));