diff --git a/pkgs/development/python-modules/pyqt/4.x.nix b/pkgs/development/python-modules/pyqt/4.x.nix
deleted file mode 100644
index a0bf3f03f600..000000000000
--- a/pkgs/development/python-modules/pyqt/4.x.nix
+++ /dev/null
@@ -1,69 +0,0 @@
-{ lib, stdenv, fetchurl, buildPythonPackage, python, dbus-python, sip_4, qt4, pkg-config, lndir, dbus, makeWrapper }:
-
-buildPythonPackage rec {
-  pname = "PyQt-x11-gpl";
-  version = "4.12.3";
-  format = "other";
-
-  src = fetchurl {
-    url = "mirror://sourceforge/pyqt/PyQt4_gpl_x11-${version}.tar.gz";
-    sha256 = "0wnlasg62rm5d39nq1yw4namcx2ivxgzl93r5f2vb9s0yaz5l3x0";
-  };
-
-  postPatch = ''
-    mkdir -p $out
-    lndir ${dbus-python} $out
-    rm -rf "$out/nix-support"
-
-    export PYTHONPATH=$PYTHONPATH:$out/lib/${python.libPrefix}/site-packages
-    ${lib.optionalString stdenv.isDarwin ''
-      export QMAKESPEC="unsupported/macx-clang-libc++" # macOS target after bootstrapping phase \
-    ''}
-
-    substituteInPlace configure.py \
-      --replace 'install_dir=pydbusmoddir' "install_dir='$out/lib/${python.libPrefix}/site-packages/dbus/mainloop'" \
-    ${lib.optionalString stdenv.isDarwin ''
-      --replace "qt_macx_spec = 'macx-g++'" "qt_macx_spec = 'unsupported/macx-clang-libc++'" # for bootstrapping phase \
-    ''}
-
-    chmod +x configure.py
-    sed -i '1i#!${python.pythonForBuild.interpreter}' configure.py
-  '';
-
-  configureScript = "./configure.py";
-  dontAddPrefix = true;
-  configureFlags = [
-    "--confirm-license"
-    "--bindir=${placeholder "out"}/bin"
-    "--destdir=${placeholder "out"}/${python.sitePackages}"
-    "--plugin-destdir=${placeholder "out"}/lib/qt4/plugins"
-    "--sipdir=${placeholder "out"}/share/sip/PyQt4"
-    "--dbus=${lib.getDev dbus-python}/include/dbus-1.0"
-    "--verbose"
-  ];
-
-  nativeBuildInputs = [ pkg-config lndir makeWrapper qt4 ];
-  buildInputs = [ qt4 dbus ];
-
-  propagatedBuildInputs = [ sip_4 ];
-
-  postInstall = ''
-    for i in $out/bin/*; do
-      wrapProgram $i --prefix PYTHONPATH : "$PYTHONPATH"
-    done
-  '';
-
-  enableParallelBuilding = true;
-
-  passthru = {
-    qt = qt4;
-  };
-
-  meta = with lib; {
-    description = "Python bindings for Qt";
-    license = "GPL";
-    homepage = "http://www.riverbankcomputing.co.uk";
-    maintainers = [ maintainers.sander ];
-    platforms = platforms.mesaPlatforms;
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index cbfa6e5d2091..89ad05c16de0 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -273,6 +273,7 @@ mapAliases ({
   pymc3 = pymc; # added 2022-06-05, module was rename starting with 4.0.0
   pymssql = throw "pymssql has been abandoned upstream."; # added 2020-05-04
   PyMVGLive = pymvglive; # added 2023-02-19
+  pyqt4 = throw "pyqt4 has been removed, because it depended on the long EOL qt4"; # added 2022-06-09
   pyramid_hawkauth = throw "pyramid_hawkauth has been removed because it is no longer maintained"; # added 2023-02-2
   pyramid_jinja2 = pyramid-jinja2; # added 2023-06-06
   pyreadability = readability-lxml; # added 2022-05-24
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index 1ca51264a2ca..3c34eb74a62f 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -9691,8 +9691,6 @@ self: super: with self; {
 
   pyqt-builder = callPackage ../development/python-modules/pyqt-builder { };
 
-  pyqt4 = callPackage ../development/python-modules/pyqt/4.x.nix { };
-
   pyqt5 = callPackage ../development/python-modules/pyqt/5.x.nix { };
 
   pyqt5_sip = callPackage ../development/python-modules/pyqt/sip.nix { };