diff --git a/pkgs/development/compilers/gcc/4.8/default.nix b/pkgs/development/compilers/gcc/4.8/default.nix
index ed185b4be1a2..60db368c403a 100644
--- a/pkgs/development/compilers/gcc/4.8/default.nix
+++ b/pkgs/development/compilers/gcc/4.8/default.nix
@@ -116,6 +116,7 @@ let version = "4.8.5";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -124,8 +125,9 @@ let version = "4.8.5";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/compilers/gcc/4.9/default.nix b/pkgs/development/compilers/gcc/4.9/default.nix
index 3f13562c1b8c..361db92cb767 100644
--- a/pkgs/development/compilers/gcc/4.9/default.nix
+++ b/pkgs/development/compilers/gcc/4.9/default.nix
@@ -121,6 +121,7 @@ let version = "4.9.4";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -129,8 +130,9 @@ let version = "4.9.4";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/compilers/gcc/5/default.nix b/pkgs/development/compilers/gcc/5/default.nix
index 497ca40c3ae6..2e51e9c05066 100644
--- a/pkgs/development/compilers/gcc/5/default.nix
+++ b/pkgs/development/compilers/gcc/5/default.nix
@@ -107,6 +107,7 @@ let version = "5.5.0";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -115,8 +116,9 @@ let version = "5.5.0";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/compilers/gcc/6/default.nix b/pkgs/development/compilers/gcc/6/default.nix
index 3f5d3172d12f..e6825afcfa84 100644
--- a/pkgs/development/compilers/gcc/6/default.nix
+++ b/pkgs/development/compilers/gcc/6/default.nix
@@ -105,6 +105,7 @@ let version = "6.4.0";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -113,11 +114,9 @@ let version = "6.4.0";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
-        # maybe only needed on musl, PATH_MAX
-        # https://github.com/richfelker/musl-cross-make/blob/0867cdf300618d1e3e87a0a939fa4427207ad9d7/litecross/Makefile#L62
-        "--disable-libmpx"
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/compilers/gcc/7/default.nix b/pkgs/development/compilers/gcc/7/default.nix
index 30c1611f5fb3..4dfbcf0f5458 100644
--- a/pkgs/development/compilers/gcc/7/default.nix
+++ b/pkgs/development/compilers/gcc/7/default.nix
@@ -77,6 +77,7 @@ let version = "7.3.0";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -85,11 +86,9 @@ let version = "7.3.0";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
-        # maybe only needed on musl, PATH_MAX
-        # https://github.com/richfelker/musl-cross-make/blob/0867cdf300618d1e3e87a0a939fa4427207ad9d7/litecross/Makefile#L62
-        "--disable-libmpx"
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/compilers/gcc/8/default.nix b/pkgs/development/compilers/gcc/8/default.nix
index 727cd9cbdbd7..04054df8bf82 100644
--- a/pkgs/development/compilers/gcc/8/default.nix
+++ b/pkgs/development/compilers/gcc/8/default.nix
@@ -72,6 +72,7 @@ let version = "8.2.0";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -80,11 +81,9 @@ let version = "8.2.0";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
-        # maybe only needed on musl, PATH_MAX
-        # https://github.com/richfelker/musl-cross-make/blob/0867cdf300618d1e3e87a0a939fa4427207ad9d7/litecross/Makefile#L62
-        "--disable-libmpx"
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/compilers/gcc/snapshot/default.nix b/pkgs/development/compilers/gcc/snapshot/default.nix
index dd6de818117f..230409e97538 100644
--- a/pkgs/development/compilers/gcc/snapshot/default.nix
+++ b/pkgs/development/compilers/gcc/snapshot/default.nix
@@ -69,6 +69,7 @@ let version = "7-20170409";
         "--enable-sjlj-exceptions"
         "--enable-threads=win32"
         "--disable-win32-registry"
+        "--disable-libmpx" # requires libc
       ] else if crossStageStatic then [
         "--disable-libssp"
         "--disable-nls"
@@ -77,8 +78,9 @@ let version = "7-20170409";
         "--disable-libgomp"
         "--disable-libquadmath"
         "--disable-shared"
-        "--disable-libatomic"  # libatomic requires libc
-        "--disable-decimal-float" # libdecnumber requires libc
+        "--disable-libatomic" # requires libc
+        "--disable-decimal-float" # requires libc
+        "--disable-libmpx" # requires libc
       ] else [
         (if crossDarwin then "--with-sysroot=${getLib libcCross}/share/sysroot"
          else                "--with-headers=${getDev libcCross}/include")
diff --git a/pkgs/development/libraries/glibc/default.nix b/pkgs/development/libraries/glibc/default.nix
index c74c27598ee0..8b17ff9e5585 100644
--- a/pkgs/development/libraries/glibc/default.nix
+++ b/pkgs/development/libraries/glibc/default.nix
@@ -94,8 +94,7 @@ callPackage ./common.nix { inherit stdenv; } {
       mv $bin/bin/getconf_ $bin/bin/getconf
     '';
 
-    # Hack to get around eval issue.
-    separateDebugInfo = !stdenv.isDarwin;
+    separateDebugInfo = true;
 
     meta.description = "The GNU C Library";
   }
diff --git a/pkgs/stdenv/cross/default.nix b/pkgs/stdenv/cross/default.nix
index 31ca9f2c82e4..daa9f66615c9 100644
--- a/pkgs/stdenv/cross/default.nix
+++ b/pkgs/stdenv/cross/default.nix
@@ -53,12 +53,15 @@ in lib.init bootStages ++ [
            else buildPackages.gcc;
 
       extraNativeBuildInputs = old.extraNativeBuildInputs
+        ++ lib.optionals
+             (hostPlatform.isLinux && !buildPlatform.isLinux)
+             [ buildPackages.patchelf buildPackages.paxctl ]
+        ++ lib.optional
+             (let f = p: !p.isx86 || p.libc == "musl"; in f hostPlatform && !(f buildPlatform))
+             buildPackages.updateAutotoolsGnuConfigScriptsHook
            # without proper `file` command, libtool sometimes fails
            # to recognize 64-bit DLLs
         ++ lib.optional (hostPlatform.config == "x86_64-w64-mingw32") buildPackages.file
-        ++ lib.optional
-             (hostPlatform.isAarch64 || hostPlatform.isMips || hostPlatform.libc == "musl")
-             buildPackages.updateAutotoolsGnuConfigScriptsHook
         ;
     });
   })
diff --git a/pkgs/stdenv/generic/make-derivation.nix b/pkgs/stdenv/generic/make-derivation.nix
index e1ce3200e8c9..c663c3743ed6 100644
--- a/pkgs/stdenv/generic/make-derivation.nix
+++ b/pkgs/stdenv/generic/make-derivation.nix
@@ -83,9 +83,7 @@ rec {
       doCheck' = doCheck && stdenv.hostPlatform == stdenv.buildPlatform;
       doInstallCheck' = doInstallCheck && stdenv.hostPlatform == stdenv.buildPlatform;
 
-      outputs' =
-        outputs ++
-        (if separateDebugInfo then assert stdenv.hostPlatform.isLinux; [ "debug" ] else []);
+      outputs' = outputs ++ lib.optional separateDebugInfo "debug";
 
       fixedOutputDrv = attrs ? outputHash;
       noNonNativeDeps = builtins.length (depsBuildTarget ++ depsBuildTargetPropagated
@@ -176,7 +174,7 @@ rec {
         // {
           # A hack to make `nix-env -qa` and `nix search` ignore broken packages.
           # TODO(@oxij): remove this assert when something like NixOS/nix#1771 gets merged into nix.
-          name = assert validity.handled; name + lib.optionalString
+          name = assert validity.handled && (separateDebugInfo -> stdenv.hostPlatform.isLinux); name + lib.optionalString
             # Fixed-output derivations like source tarballs shouldn't get a host
             # suffix. But we have some weird ones with run-time deps that are
             # just used for their side-affects. Those might as well since the
diff --git a/pkgs/stdenv/linux/default.nix b/pkgs/stdenv/linux/default.nix
index b29a96314d2c..08703b6934e5 100644
--- a/pkgs/stdenv/linux/default.nix
+++ b/pkgs/stdenv/linux/default.nix
@@ -251,7 +251,8 @@ in
     };
     extraNativeBuildInputs = [ prevStage.patchelf prevStage.paxctl ] ++
       # Many tarballs come with obsolete config.sub/config.guess that don't recognize aarch64.
-      lib.optional (!localSystem.isx86) prevStage.updateAutotoolsGnuConfigScriptsHook;
+      lib.optional (!localSystem.isx86 || localSystem.libc == "musl")
+                   prevStage.updateAutotoolsGnuConfigScriptsHook;
   })
 
 
@@ -292,7 +293,8 @@ in
     };
     extraNativeBuildInputs = [ prevStage.patchelf prevStage.xz ] ++
       # Many tarballs come with obsolete config.sub/config.guess that don't recognize aarch64.
-      lib.optional (!localSystem.isx86) prevStage.updateAutotoolsGnuConfigScriptsHook;
+      lib.optional (!localSystem.isx86 || localSystem.libc == "musl")
+                   prevStage.updateAutotoolsGnuConfigScriptsHook;
   })
 
   # Construct the final stdenv.  It uses the Glibc and GCC, and adds
@@ -324,7 +326,8 @@ in
 
       extraNativeBuildInputs = [ prevStage.patchelf prevStage.paxctl ] ++
         # Many tarballs come with obsolete config.sub/config.guess that don't recognize aarch64.
-        lib.optional (!localSystem.isx86) prevStage.updateAutotoolsGnuConfigScriptsHook;
+        lib.optional (!localSystem.isx86 || localSystem.libc == "musl")
+        prevStage.updateAutotoolsGnuConfigScriptsHook;
 
       cc = prevStage.gcc;
 
@@ -357,7 +360,7 @@ in
         ++  [ /*propagated from .dev*/ linuxHeaders
             binutils gcc gcc.cc gcc.cc.lib gcc.expand-response-params
           ]
-          ++ lib.optionals (!localSystem.isx86)
+          ++ lib.optionals (!localSystem.isx86 || localSystem.libc == "musl")
             [ prevStage.updateAutotoolsGnuConfigScriptsHook prevStage.gnu-config ];
 
       overrides = self: super: {
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 0b995e561f2d..07133473b808 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -6509,7 +6509,6 @@ with pkgs;
     libcCross1 =
       if stdenv.targetPlatform.libc == "msvcrt" then targetPackages.windows.mingw_w64_headers
       else if stdenv.targetPlatform.libc == "libSystem" then darwin.xcode
-      else if stdenv.targetPlatform.libc == "musl" then musl
       else null;
     binutils1 = wrapBintoolsWith {
       bintools = binutils-unwrapped;