diff --git a/pkgs/applications/audio/musescore/darwin.nix b/pkgs/applications/audio/musescore/darwin.nix
deleted file mode 100644
index 652adb03b66a..000000000000
--- a/pkgs/applications/audio/musescore/darwin.nix
+++ /dev/null
@@ -1,35 +0,0 @@
-{ stdenv, lib, fetchurl, undmg }:
-
-let
-  versionComponents = [ "4" "0" "1" ];
-  appName = "MuseScore ${builtins.head versionComponents}";
-  ref = "230121751";
-in
-
-stdenv.mkDerivation rec {
-  pname = "musescore-darwin";
-  version = lib.concatStringsSep "." versionComponents;
-
-  # The disk image contains the .app and a symlink to /Applications.
-  sourceRoot = "${appName}.app";
-
-  src = fetchurl {
-    url =  "https://github.com/musescore/MuseScore/releases/download/v${version}/MuseScore-${version}.${ref}.dmg";
-    hash = "sha256-tkIEV+tCS0SYh2TlC70/zEBUEOSg//EaSKDGA7kH/vo=";
-  };
-
-  buildInputs = [ undmg ];
-  installPhase = ''
-    mkdir -p "$out/Applications/${appName}.app"
-    cp -R . "$out/Applications/${appName}.app"
-    chmod a+x "$out/Applications/${appName}.app/Contents/MacOS/mscore"
-  '';
-
-  meta = with lib; {
-    description = "Music notation and composition software";
-    homepage = "https://musescore.org/";
-    license = licenses.gpl3Only;
-    platforms = platforms.darwin;
-    maintainers = [];
-  };
-}
diff --git a/pkgs/applications/audio/musescore/default.nix b/pkgs/applications/audio/musescore/default.nix
index 15828d25729c..fa166051db61 100644
--- a/pkgs/applications/audio/musescore/default.nix
+++ b/pkgs/applications/audio/musescore/default.nix
@@ -1,55 +1,143 @@
-{ mkDerivation, lib, fetchFromGitHub, fetchpatch, cmake, pkg-config, ninja
-, alsa-lib, freetype, libjack2, lame, libogg, libpulseaudio, libsndfile, libvorbis
-, portaudio, portmidi, qtbase, qtdeclarative, qtgraphicaleffects, flac
-, qtquickcontrols2, qtscript, qtsvg, qttools
-, qtwebengine, qtxmlpatterns, qtnetworkauth, qtx11extras
+{ stdenv
+, lib
+, fetchFromGitHub
+, fetchpatch
+, cmake
+, wrapQtAppsHook
+, pkg-config
+, ninja
+, alsa-lib
+, freetype
+, libjack2
+, lame
+, libogg
+, libpulseaudio
+, libsndfile
+, libvorbis
+, portaudio
+, portmidi
+, qtbase
+, qtdeclarative
+, qtgraphicaleffects
+, flac
+, qtquickcontrols
+, qtquickcontrols2
+, qtscript
+, qtsvg
+, qtxmlpatterns
+, qtnetworkauth
+, qtx11extras
 , nixosTests
+, darwin
 }:
 
-mkDerivation rec {
+let
+  stdenv' = if stdenv.isDarwin then darwin.apple_sdk_11_0.stdenv else stdenv;
+  # portaudio propagates Darwin frameworks. Rebuild it using the 11.0 stdenv
+  # from Qt and the 11.0 SDK frameworks.
+  portaudio' = if stdenv.isDarwin then portaudio.override {
+    stdenv = stdenv';
+    inherit (darwin.apple_sdk_11_0.frameworks)
+      AudioUnit
+      AudioToolbox
+      CoreAudio
+      CoreServices
+      Carbon
+    ;
+  } else portaudio;
+in stdenv'.mkDerivation rec {
   pname = "musescore";
-  version = "4.0.2";
+  version = "4.1.0";
 
   src = fetchFromGitHub {
     owner = "musescore";
     repo = "MuseScore";
     rev = "v${version}";
-    sha256 = "sha256-3NSHUdTyAC/WOhkB6yBrqtV3LV4Hl1m3poB3ojtJMfs=";
+    sha256 = "sha256-CqW1f0VsF2lW79L3FY2ev+6FoHLbYOJ9LWHeBlWegeU=";
   };
   patches = [
-    # See https://github.com/musescore/MuseScore/issues/15571
+    # Upstream from some reason wants to install qml files from qtbase in
+    # installPhase, this patch removes this behavior. See:
+    # https://github.com/musescore/MuseScore/issues/18665
     (fetchpatch {
-      url = "https://github.com/musescore/MuseScore/commit/365be5dfb7296ebee4677cb74b67c1721bc2cf7b.patch";
-      hash = "sha256-tJ2M21i3geO9OsjUQKNatSXTkJ5U9qMT4RLNdJnyoKw=";
+      url = "https://github.com/doronbehar/MuseScore/commit/f48448a3ede46f5a7ef470940072fbfb6742487c.patch";
+      hash = "sha256-UEc7auscnW0KMfWkLKQtm+UstuTNsuFeoNJYIidIlwM=";
     })
   ];
 
   cmakeFlags = [
-    "-DMUSESCORE_BUILD_CONFIG=release"
-    # Disable the _usage_ of the `/bin/crashpad_handler` utility. See:
-    # https://github.com/musescore/MuseScore/pull/15577
-    "-DBUILD_CRASHPAD_CLIENT=OFF"
+    "-DMUSESCORE_BUILD_MODE=release"
+    # Disable the build and usage of the `/bin/crashpad_handler` utility - it's
+    # not useful on NixOS, see:
+    # https://github.com/musescore/MuseScore/issues/15571
+    "-DMUE_BUILD_CRASHPAD_CLIENT=OFF"
     # Use our freetype
     "-DUSE_SYSTEM_FREETYPE=ON"
+    # From some reason, in $src/build/cmake/SetupBuildEnvironment.cmake,
+    # upstream defaults to compiling to x86_64 only, unless this cmake flag is
+    # set
+    "-DMUE_COMPILE_BUILD_MACOS_APPLE_SILICON=ON"
+    # Don't bundle qt qml files, relevant really only for darwin, but we set
+    # this for all platforms anyway.
+    "-DMUE_COMPILE_INSTALL_QTQML_FILES=OFF"
   ];
 
   qtWrapperArgs = [
     # MuseScore JACK backend loads libjack at runtime.
-    "--prefix LD_LIBRARY_PATH : ${lib.makeLibraryPath [ libjack2 ]}"
+    "--prefix ${lib.optionalString stdenv.isDarwin "DY"}LD_LIBRARY_PATH : ${lib.makeLibraryPath [ libjack2 ]}"
+  ] ++ lib.optionals (!stdenv.isDarwin) [
     # There are some issues with using the wayland backend, see:
     # https://musescore.org/en/node/321936
     "--set-default QT_QPA_PLATFORM xcb"
   ];
 
-  nativeBuildInputs = [ cmake pkg-config ninja ];
+  # HACK `propagatedSandboxProfile` does not appear to actually propagate the
+  # sandbox profile from `qtbase`, see:
+  # https://github.com/NixOS/nixpkgs/issues/237458
+  sandboxProfile = toString qtbase.__propagatedSandboxProfile or null;
+
+  nativeBuildInputs = [
+    wrapQtAppsHook
+    cmake
+    pkg-config
+    ninja
+  ];
 
   buildInputs = [
-    alsa-lib libjack2 freetype lame libogg libpulseaudio libsndfile libvorbis
-    portaudio portmidi flac # tesseract
-    qtbase qtdeclarative qtgraphicaleffects qtquickcontrols2
-    qtscript qtsvg qttools qtwebengine qtxmlpatterns qtnetworkauth qtx11extras
+    libjack2
+    freetype
+    lame
+    libogg
+    libpulseaudio
+    libsndfile
+    libvorbis
+    portaudio'
+    portmidi
+    flac
+    qtbase
+    qtdeclarative
+    qtgraphicaleffects
+    qtquickcontrols
+    qtquickcontrols2
+    qtscript
+    qtsvg
+    qtxmlpatterns
+    qtnetworkauth
+    qtx11extras
+  ] ++ lib.optionals stdenv.isLinux [
+    alsa-lib
   ];
 
+  postInstall = ''
+    # Remove unneeded bundled libraries and headers
+    rm -r $out/{include,lib}
+  '' + lib.optionalString stdenv.isDarwin ''
+    mkdir -p "$out/Applications"
+    mv "$out/mscore.app" "$out/Applications/mscore.app"
+    mkdir -p $out/bin
+    ln -s $out/Applications/mscore.app/Contents/MacOS/mscore $out/bin/mscore.
+  '';
+
   passthru.tests = nixosTests.musescore;
 
   meta = with lib; {
@@ -57,9 +145,9 @@ mkDerivation rec {
     homepage = "https://musescore.org/";
     license = licenses.gpl3Only;
     maintainers = with maintainers; [ vandenoever turion doronbehar ];
-    # Darwin requires CoreMIDI from SDK 11.3, we use the upstream built .dmg
-    # file in ./darwin.nix in the meantime.
-    platforms = platforms.linux;
+    # on aarch64-linux:
+    # error: cannot convert '<brace-enclosed initializer list>' to 'float32x4_t' in assignment
+    broken = (stdenv.isLinux && stdenv.isAarch64);
     mainProgram = "mscore";
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 9646ec6e0311..39f4d3a3aa04 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -33441,12 +33441,7 @@ with pkgs;
     autoreconfHook = buildPackages.autoreconfHook269;
   };
 
-  # TODO: we should probably merge these 2
-  musescore =
-    if stdenv.isDarwin then
-      callPackage ../applications/audio/musescore/darwin.nix { }
-    else
-      libsForQt5.callPackage ../applications/audio/musescore { };
+  musescore = libsForQt5.callPackage ../applications/audio/musescore { };
 
   music-player = callPackage ../applications/audio/music-player { };