diff --git a/pkgs/applications/misc/redshift/default.nix b/pkgs/applications/misc/redshift/default.nix
index 9871c559523c..c0e481ae8788 100644
--- a/pkgs/applications/misc/redshift/default.nix
+++ b/pkgs/applications/misc/redshift/default.nix
@@ -41,7 +41,10 @@ stdenv.mkDerivation rec {
   pythonPath = [ pygobject3 pyxdg ];
 
   preConfigure = "./bootstrap";
-  postFixup = "wrapPythonPrograms";
+  postFixup = ''
+    wrapPythonPrograms
+    rm "$out/share/icons/hicolor/icon-theme.cache"
+  '';
 
   enableParallelBuilding = true;
 
diff --git a/pkgs/applications/networking/newsreaders/liferea/default.nix b/pkgs/applications/networking/newsreaders/liferea/default.nix
index 743da7958067..ed6fe17cc7e8 100644
--- a/pkgs/applications/networking/newsreaders/liferea/default.nix
+++ b/pkgs/applications/networking/newsreaders/liferea/default.nix
@@ -28,6 +28,7 @@ in stdenv.mkDerivation rec {
   pythonPath = with python3Packages; [ pygobject3 pycairo ];
 
   preFixup = ''
+    rm "$out/share/icons/hicolor/icon-theme.cache"
     buildPythonPath "$out $pythonPath"
     gappsWrapperArgs+=(--prefix PYTHONPATH : "$program_PYTHONPATH")
   '';