diff --git a/pkgs/development/python-modules/eth-keyfile/default.nix b/pkgs/development/python-modules/eth-keyfile/default.nix
index b52dde5df2d4..e8e42a56c60f 100644
--- a/pkgs/development/python-modules/eth-keyfile/default.nix
+++ b/pkgs/development/python-modules/eth-keyfile/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchFromGitHub
+, setuptools
 , eth-keys
 , eth-utils
 , pycryptodome
@@ -10,22 +11,19 @@
 
 buildPythonPackage rec {
   pname = "eth-keyfile";
-  version = "0.6.0";
-  format = "setuptools";
-  disabled = pythonOlder "3.7";
+  version = "0.8.0";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
 
   src = fetchFromGitHub {
     owner = "ethereum";
     repo = "eth-keyfile";
     rev = "v${version}";
     fetchSubmodules = true;
-    hash = "sha256-JD4bRoD9L0JXcd+bTZrq/BkWw5QGzOi1RvoyLJC77kk=";
+    hash = "sha256-797yhHuU9/lm96YKxl3SZ5IQAwDxDSYkLkiBdAHh0Uk=";
   };
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace "'setuptools-markdown'" ""
-  '';
+  build-system = [ setuptools];
 
   propagatedBuildInputs = [
     eth-keys
diff --git a/pkgs/development/python-modules/eth-keys/default.nix b/pkgs/development/python-modules/eth-keys/default.nix
index 3f6c633c6487..edf83f065701 100644
--- a/pkgs/development/python-modules/eth-keys/default.nix
+++ b/pkgs/development/python-modules/eth-keys/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchFromGitHub
+, setuptools
 , asn1tools
 , coincurve
 , eth-hash
@@ -16,17 +17,19 @@
 
 buildPythonPackage rec {
   pname = "eth-keys";
-  version = "0.4.0";
-  format = "setuptools";
-  disabled = pythonOlder "3.6";
+  version = "0.5.0";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
 
   src = fetchFromGitHub {
     owner = "ethereum";
     repo = "eth-keys";
     rev = "v${version}";
-    hash = "sha256-jG/jJPM4t3z6UQIdc8L6y0DxZiGx5pVuGL8XwbIt60o=";
+    hash = "sha256-vyyaLCG2uIHXX0t93DmFq8/u0rZL+nsBsH2gfgjziyo=";
   };
 
+  build-system = [ setuptools];
+
   propagatedBuildInputs = [
     eth-typing
     eth-utils
diff --git a/pkgs/development/python-modules/eth-rlp/default.nix b/pkgs/development/python-modules/eth-rlp/default.nix
index 0a54bef3a2c1..081abf233ef9 100644
--- a/pkgs/development/python-modules/eth-rlp/default.nix
+++ b/pkgs/development/python-modules/eth-rlp/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchFromGitHub
+, setuptools
 , eth-hash
 , eth-utils
 , hexbytes
@@ -11,17 +12,19 @@
 
 buildPythonPackage rec {
   pname = "eth-rlp";
-  version = "0.3.0";
-  format = "setuptools";
-  disabled = pythonOlder "3.7";
+  version = "2.1.0";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
 
   src = fetchFromGitHub {
     owner = "ethereum";
     repo = "eth-rlp";
     rev = "v${version}";
-    hash = "sha256-wfmRjHFu6H3J6hNin8ZA2454xXrLgcUdeR8iGXFomRE=";
+    hash = "sha256-FTqIutndf+epmO5XNEUoRAUEmn299aTLIZNe5SMcxAQ=";
   };
 
+  build-system = [ setuptools];
+
   propagatedBuildInputs = [
     hexbytes
     eth-utils
diff --git a/pkgs/development/python-modules/hexbytes/default.nix b/pkgs/development/python-modules/hexbytes/default.nix
index 9bfb9918bf32..654471ca0f29 100644
--- a/pkgs/development/python-modules/hexbytes/default.nix
+++ b/pkgs/development/python-modules/hexbytes/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchFromGitHub
+, setuptools
 , eth-utils
 , hypothesis
 , pytestCheckHook
@@ -9,18 +10,19 @@
 
 buildPythonPackage rec {
   pname = "hexbytes";
-  version = "0.3.1";
-  format = "setuptools";
-
-  disabled = pythonOlder "3.7";
+  version = "1.2.0";
+  pyproject = true;
+  disabled = pythonOlder "3.8";
 
   src = fetchFromGitHub {
     owner = "ethereum";
     repo = "hexbytes";
     rev = "refs/tags/v${version}";
-    hash = "sha256-19oY/VPP6qkxHCkIgpC28fOOYKEYcNbVVGoHJmMmOl8=";
+    hash = "sha256-8st1nQiGApt+aNl8/cftYk0ZzA+MxbLyGi53UWUlAjM=";
   };
 
+  build-system = [ setuptools];
+
   nativeCheckInputs = [
     eth-utils
     hypothesis
diff --git a/pkgs/development/python-modules/rlp/default.nix b/pkgs/development/python-modules/rlp/default.nix
index 9938ad1c4410..8aeee9d0dd9c 100644
--- a/pkgs/development/python-modules/rlp/default.nix
+++ b/pkgs/development/python-modules/rlp/default.nix
@@ -1,5 +1,6 @@
 { lib
 , fetchFromGitHub
+, setuptools
 , buildPythonPackage
 , eth-utils
 , hypothesis
@@ -8,20 +9,17 @@
 
 buildPythonPackage rec {
   pname = "rlp";
-  version = "3.0.0";
-  format = "setuptools";
+  version = "4.0.0";
+  pyproject = true;
 
   src = fetchFromGitHub {
     owner = "ethereum";
     repo = "pyrlp";
     rev = "v${version}";
-    hash = "sha256-GRCq4FU38e08fREg5fweig5Y60jLT2k3Yj1Jk8OA6XY=";
+    hash = "sha256-cRp+ZOPYs9kcqMKGaiYMOFBY+aPCyFqu+1/5wloLwqU=";
   };
 
-  postPatch = ''
-    substituteInPlace setup.py \
-      --replace "'setuptools-markdown'" ""
-  '';
+  build-system = [ setuptools];
 
   propagatedBuildInputs = [
     eth-utils
diff --git a/pkgs/development/python-modules/slither-analyzer/default.nix b/pkgs/development/python-modules/slither-analyzer/default.nix
index bccc5b97f728..2dc276bac48b 100644
--- a/pkgs/development/python-modules/slither-analyzer/default.nix
+++ b/pkgs/development/python-modules/slither-analyzer/default.nix
@@ -7,7 +7,7 @@
 , packaging
 , prettytable
 , pythonOlder
-, setuptools
+, setuptools-scm
 , solc
 , web3
 , withSolc ? false
@@ -17,7 +17,7 @@
 
 buildPythonPackage rec {
   pname = "slither-analyzer";
-  version = "0.10.1";
+  version = "0.10.2";
   pyproject = true;
 
   disabled = pythonOlder "3.8";
@@ -26,12 +26,12 @@ buildPythonPackage rec {
     owner = "crytic";
     repo = "slither";
     rev = "refs/tags/${version}";
-    hash = "sha256-MjO2ZYFat+byH0DEt2v/wPXaYL2lmlESgQCZXD4Jpt0=";
+    hash = "sha256-KmbmljtmMtrJxgSMJjQ8fdk6RpEXcAVBuo24EsyMV8k=";
   };
 
   nativeBuildInputs = [
     makeWrapper
-    setuptools
+    setuptools-scm
   ];
 
   propagatedBuildInputs = [
@@ -68,14 +68,19 @@ buildPythonPackage rec {
     "slither.vyper_parsing"
   ];
 
-  # No Python tests
-  doCheck = false;
+  # Test if the binary works during the build phase.
+  checkPhase = ''
+    runHook preCheck
 
-  passthru.tests = {
-    version = testers.testVersion {
-      package = slither-analyzer;
-      command = "HOME=$TMPDIR slither --version";
-    };
+    HOME="$TEMP" $out/bin/slither --version
+
+    runHook postCheck
+  '';
+
+  passthru.tests.version = testers.testVersion {
+    package = slither-analyzer;
+    command = "HOME=$TMPDIR slither --version";
+    version = "${version}";
   };
 
   meta = with lib; {