diff --git a/pkgs/applications/audio/galaxy-buds-client/default.nix b/pkgs/applications/audio/galaxy-buds-client/default.nix
index 15125358e464..6dd2256d7c8a 100644
--- a/pkgs/applications/audio/galaxy-buds-client/default.nix
+++ b/pkgs/applications/audio/galaxy-buds-client/default.nix
@@ -2,7 +2,6 @@
 , stdenv
 , buildDotnetModule
 , fetchFromGitHub
-, autoPatchelfHook
 , fontconfig
 , xorg
 , libglvnd
@@ -27,7 +26,6 @@ buildDotnetModule rec {
   dotnetFlags = [ "-p:Runtimeidentifier=linux-x64" ];
 
   nativeBuildInputs = [
-    autoPatchelfHook
     copyDesktopItems
     graphicsmagick
   ];
diff --git a/pkgs/applications/blockchains/wasabibackend/default.nix b/pkgs/applications/blockchains/wasabibackend/default.nix
index 79355f3979dc..1371be1a9752 100644
--- a/pkgs/applications/blockchains/wasabibackend/default.nix
+++ b/pkgs/applications/blockchains/wasabibackend/default.nix
@@ -4,7 +4,6 @@
   fetchFromGitHub,
   buildDotnetModule,
   dotnetCorePackages,
-  autoPatchelfHook,
   zlib,
   openssl,
 }:
@@ -25,7 +24,6 @@ buildDotnetModule rec {
   dotnet-sdk = dotnetCorePackages.sdk_7_0;
   dotnet-runtime = dotnetCorePackages.aspnetcore_7_0;
 
-  nativeBuildInputs = [autoPatchelfHook];
   buildInputs = [stdenv.cc.cc.lib zlib];
 
   runtimeDeps = [openssl zlib];
diff --git a/pkgs/applications/misc/avalonia-ilspy/default.nix b/pkgs/applications/misc/avalonia-ilspy/default.nix
index 797a8ffe5c93..d8ae98e66acd 100644
--- a/pkgs/applications/misc/avalonia-ilspy/default.nix
+++ b/pkgs/applications/misc/avalonia-ilspy/default.nix
@@ -15,7 +15,6 @@
 , makeDesktopItem
 , copyDesktopItems
 , icoutils
-, autoPatchelfHook
 , bintools
 , fixDarwinDylibNames
 , autoSignDarwinBinariesHook
@@ -40,8 +39,7 @@ buildDotnetModule rec {
   nativeBuildInputs = [
     copyDesktopItems
     icoutils
-  ] ++ lib.optionals stdenv.hostPlatform.isLinux [ autoPatchelfHook ]
-    ++ lib.optionals stdenv.hostPlatform.isDarwin [ bintools fixDarwinDylibNames ]
+  ] ++ lib.optionals stdenv.hostPlatform.isDarwin [ bintools fixDarwinDylibNames ]
     ++ lib.optionals (stdenv.hostPlatform.isDarwin && stdenv.hostPlatform.isAarch64) [ autoSignDarwinBinariesHook ];
 
   buildInputs = [
diff --git a/pkgs/development/compilers/inklecate/default.nix b/pkgs/development/compilers/inklecate/default.nix
index fa701d8fd269..52c278a1bd30 100644
--- a/pkgs/development/compilers/inklecate/default.nix
+++ b/pkgs/development/compilers/inklecate/default.nix
@@ -1,6 +1,5 @@
 { lib
 , stdenv
-, autoPatchelfHook
 , buildDotnetModule
 , dotnetCorePackages
 , fetchFromGitHub
@@ -17,7 +16,6 @@ buildDotnetModule rec {
     hash = "sha512-aUjjT5Qf64wrKRn1vkwJadMOBWMkvsXUjtZ7S3/ZWAh1CCDkQNO84mSbtbVc9ny0fKeJEqaDX2tJNwq7pYqAbA==";
   };
 
-  nativeBuildInputs = lib.optionals stdenv.isLinux [ autoPatchelfHook ];
   buildInputs = [ stdenv.cc.cc.lib ];
 
   projectFile = "inklecate/inklecate.csproj";
diff --git a/pkgs/development/tools/continuous-integration/github-runner/default.nix b/pkgs/development/tools/continuous-integration/github-runner/default.nix
index e9aace248d86..34aaf68bb0ff 100644
--- a/pkgs/development/tools/continuous-integration/github-runner/default.nix
+++ b/pkgs/development/tools/continuous-integration/github-runner/default.nix
@@ -1,5 +1,4 @@
-{ autoPatchelfHook
-, autoSignDarwinBinariesHook
+{ autoSignDarwinBinariesHook
 , buildDotnetModule
 , dotnetCorePackages
 , fetchFromGitHub
@@ -114,8 +113,6 @@ buildDotnetModule rec {
   nativeBuildInputs = [
     which
     git
-  ] ++ lib.optionals stdenv.isLinux [
-    autoPatchelfHook
   ] ++ lib.optionals (stdenv.isDarwin && stdenv.isAarch64) [
     autoSignDarwinBinariesHook
   ];
diff --git a/pkgs/tools/games/opentracker/default.nix b/pkgs/tools/games/opentracker/default.nix
index 6bb5fc8ff207..5bab19fa2ad9 100644
--- a/pkgs/tools/games/opentracker/default.nix
+++ b/pkgs/tools/games/opentracker/default.nix
@@ -3,7 +3,6 @@
   stdenv,
   buildDotnetModule,
   fetchFromGitHub,
-  autoPatchelfHook,
   wrapGAppsHook,
   dotnetCorePackages,
   fontconfig,
@@ -40,7 +39,6 @@ buildDotnetModule rec {
   ];
 
   nativeBuildInputs = [
-    autoPatchelfHook
     wrapGAppsHook
   ];
 
@@ -64,12 +62,6 @@ buildDotnetModule rec {
       libXi
     ]);
 
-  # Attempts to patchelf unneeded SOs
-  autoPatchelfIgnoreMissingDeps = [
-    "libc.musl-x86_64.so.1"
-    "libintl.so.8"
-  ];
-
   meta = with lib; {
     description = "A tracking application for A Link to the Past Randomizer";
     homepage = "https://github.com/trippsc2/OpenTracker";
diff --git a/pkgs/tools/networking/mqttmultimeter/default.nix b/pkgs/tools/networking/mqttmultimeter/default.nix
index e2d6f4e6fbd3..1c2c290bef78 100644
--- a/pkgs/tools/networking/mqttmultimeter/default.nix
+++ b/pkgs/tools/networking/mqttmultimeter/default.nix
@@ -4,7 +4,6 @@
 , dotnet-runtime_8
 , buildDotnetModule
 , fetchFromGitHub
-, autoPatchelfHook
 , fontconfig
 , xorg
 , libglvnd
@@ -12,9 +11,6 @@
 , copyDesktopItems
 }:
 
-# NOTES:
-# 1. we need autoPatchelfHook for quite a number of things in $out/lib
-
 buildDotnetModule rec {
   pname = "mqttmultimeter";
   version = "1.8.2.272";
@@ -35,13 +31,11 @@ buildDotnetModule rec {
   executables = [ "mqttMultimeter" ];
 
   nativeBuildInputs = [
-    autoPatchelfHook
     copyDesktopItems
   ];
 
   buildInputs = [ stdenv.cc.cc.lib fontconfig ];
 
-  # don't care about musl and windows versions, as they fail autoPatchelfHook
   postInstall = ''
     rm -rf $out/lib/${lib.toLower pname}/runtimes/{*musl*,win*}
   '';