diff --git a/pkgs/desktops/gnome/misc/gnome-extensions-cli/default.nix b/pkgs/desktops/gnome/misc/gnome-extensions-cli/default.nix
index 03f5075a791f..e7d18a0d3c0d 100644
--- a/pkgs/desktops/gnome/misc/gnome-extensions-cli/default.nix
+++ b/pkgs/desktops/gnome/misc/gnome-extensions-cli/default.nix
@@ -33,6 +33,7 @@ buildPythonApplication rec {
 
   pythonRelaxDeps = [
     "more-itertools"
+    "packaging"
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/compilers/vyper/default.nix b/pkgs/development/compilers/vyper/default.nix
index fb83f299bd8c..078cb7dac925 100644
--- a/pkgs/development/compilers/vyper/default.nix
+++ b/pkgs/development/compilers/vyper/default.nix
@@ -57,6 +57,7 @@ buildPythonPackage rec {
 
   pythonRelaxDeps = [
     "asttokens"
+    "packaging"
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/python-modules/chex/default.nix b/pkgs/development/python-modules/chex/default.nix
index 559d047032c6..08ce0916c25e 100644
--- a/pkgs/development/python-modules/chex/default.nix
+++ b/pkgs/development/python-modules/chex/default.nix
@@ -2,6 +2,7 @@
 , buildPythonPackage
 , pythonOlder
 , fetchFromGitHub
+, setuptools
 , absl-py
 , cloudpickle
 , dm-tree
@@ -15,8 +16,8 @@
 
 buildPythonPackage rec {
   pname = "chex";
-  version = "0.1.85";
-  format = "setuptools";
+  version = "0.1.86";
+  pyproject = true;
 
   disabled = pythonOlder "3.9";
 
@@ -24,10 +25,14 @@ buildPythonPackage rec {
     owner = "deepmind";
     repo = "chex";
     rev = "refs/tags/v${version}";
-    hash = "sha256-7k/+2dNNbPBXtbabuOEVpAI7T1SuM4JDf074dmTg/vs=";
+    hash = "sha256-Z5Ns4fG5pC99I4xdGjDMKX6YZpTtd1y0TWcIOtr7dug=";
   };
 
-  propagatedBuildInputs = [
+  build-system = [
+    setuptools
+  ];
+
+  dependencies = [
     absl-py
     jaxlib
     jax
diff --git a/pkgs/development/python-modules/diffsync/default.nix b/pkgs/development/python-modules/diffsync/default.nix
index 877322259c42..ff96650b920f 100644
--- a/pkgs/development/python-modules/diffsync/default.nix
+++ b/pkgs/development/python-modules/diffsync/default.nix
@@ -27,6 +27,11 @@ buildPythonPackage rec {
     pythonRelaxDepsHook
   ];
 
+  pythonRelaxDeps = [
+    "packaging"
+    "structlog"
+  ];
+
   propagatedBuildInputs = [
     colorama
     packaging
@@ -35,10 +40,6 @@ buildPythonPackage rec {
     structlog
   ];
 
-  pythonRelaxDeps = [
-    "structlog"
-  ];
-
   pythonImportsCheck = [
     "diffsync"
   ];
diff --git a/pkgs/development/python-modules/ed25519/default.nix b/pkgs/development/python-modules/ed25519/default.nix
index 7b2c20c39a04..745c2c38cd0d 100644
--- a/pkgs/development/python-modules/ed25519/default.nix
+++ b/pkgs/development/python-modules/ed25519/default.nix
@@ -1,10 +1,13 @@
-{ lib, fetchPypi, buildPythonPackage }:
+{ lib, fetchPypi, buildPythonPackage, pythonAtLeast }:
 
 buildPythonPackage rec {
   pname = "ed25519";
   version = "1.5";
   format = "setuptools";
 
+  # last commit in 2019, various compat issues with 3.12
+  disabled = pythonAtLeast "3.12";
+
   src = fetchPypi {
     inherit pname version;
     sha256 = "0n1k83ww0pr4q6z0h7p8hvy21hcgb96jvgllfbwhvvyf37h3w182";
diff --git a/pkgs/development/python-modules/flet/default.nix b/pkgs/development/python-modules/flet/default.nix
index 0dbed81022a6..3e9a7d1f7bf0 100644
--- a/pkgs/development/python-modules/flet/default.nix
+++ b/pkgs/development/python-modules/flet/default.nix
@@ -36,9 +36,10 @@ buildPythonPackage rec {
   ];
 
   pythonRelaxDeps = [
-    "websockets"
     "cookiecutter"
+    "packaging"
     "watchdog"
+    "websockets"
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/python-modules/logical-unification/default.nix b/pkgs/development/python-modules/logical-unification/default.nix
index c129202dbf16..adc6141f11db 100644
--- a/pkgs/development/python-modules/logical-unification/default.nix
+++ b/pkgs/development/python-modules/logical-unification/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchFromGitHub
+, pythonAtLeast
 , toolz
 , multipledispatch
 , py
@@ -33,6 +34,11 @@ buildPythonPackage rec {
     pytest-benchmark  # Needed for the `--benchmark-skip` flag
   ];
 
+  disabledTests = lib.optionals (pythonAtLeast "3.12") [
+    # Failed: DID NOT RAISE <class 'RecursionError'>
+    "test_reify_recursion_limit"
+  ];
+
   pytestFlagsArray = [
     "--benchmark-skip"
     "--html=testing-report.html"
diff --git a/pkgs/development/python-modules/mlflow/default.nix b/pkgs/development/python-modules/mlflow/default.nix
index 0a0efaab4372..7e25db19ffcb 100644
--- a/pkgs/development/python-modules/mlflow/default.nix
+++ b/pkgs/development/python-modules/mlflow/default.nix
@@ -56,7 +56,11 @@ buildPythonPackage rec {
     setuptools
   ];
   pythonRemoveDeps = [ "shap" ];
-  pythonRelaxDeps = [ "pytz" "pyarrow" ];
+  pythonRelaxDeps = [
+    "packaging"
+    "pytz"
+    "pyarrow"
+  ];
 
   propagatedBuildInputs = [
     alembic
diff --git a/pkgs/development/python-modules/notus-scanner/default.nix b/pkgs/development/python-modules/notus-scanner/default.nix
index 263aebada6a5..51a41bedc920 100644
--- a/pkgs/development/python-modules/notus-scanner/default.nix
+++ b/pkgs/development/python-modules/notus-scanner/default.nix
@@ -27,6 +27,7 @@ buildPythonPackage rec {
   };
 
   pythonRelaxDeps = [
+    "packaging"
     "python-gnupg"
   ];
 
diff --git a/pkgs/development/python-modules/pathtools/default.nix b/pkgs/development/python-modules/pathtools/default.nix
index 754669eb42fe..453dc9df36ef 100644
--- a/pkgs/development/python-modules/pathtools/default.nix
+++ b/pkgs/development/python-modules/pathtools/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , fetchPypi
+, pythonAtLeast
 }:
 
 buildPythonPackage rec {
@@ -8,6 +9,9 @@ buildPythonPackage rec {
   version = "0.1.2";
   format = "setuptools";
 
+  # imp and distuils usage, last commit in 2016
+  disabled = pythonAtLeast "3.12";
+
   src = fetchPypi {
     inherit pname version;
     sha256 = "1h7iam33vwxk8bvslfj4qlsdprdnwf8bvzhqh3jq5frr391cadbw";
diff --git a/pkgs/development/python-modules/rmscene/default.nix b/pkgs/development/python-modules/rmscene/default.nix
index 9e6bba74d05b..a7eb4d2c632c 100644
--- a/pkgs/development/python-modules/rmscene/default.nix
+++ b/pkgs/development/python-modules/rmscene/default.nix
@@ -1,6 +1,7 @@
 { lib
 , buildPythonPackage
 , pythonOlder
+, pythonRelaxDepsHook
 , fetchFromGitHub
 , poetry-core
 , packaging
@@ -24,6 +25,11 @@ buildPythonPackage rec {
 
   nativeBuildInputs = [
     poetry-core
+    pythonRelaxDepsHook
+  ];
+
+  pythonRelaxDeps = [
+    "packaging"
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/python-modules/streamlit/default.nix b/pkgs/development/python-modules/streamlit/default.nix
index 94144c92ab08..4ce529ef5c06 100644
--- a/pkgs/development/python-modules/streamlit/default.nix
+++ b/pkgs/development/python-modules/streamlit/default.nix
@@ -18,6 +18,7 @@
 , pympler
 , python-dateutil
 , pythonOlder
+, pythonRelaxDepsHook
 , setuptools
 , requests
 , rich
@@ -44,6 +45,11 @@ buildPythonPackage rec {
 
   nativeBuildInputs = [
     setuptools
+    pythonRelaxDepsHook
+  ];
+
+  pythonRelaxDeps = [
+    "packaging"
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/python-modules/woob/default.nix b/pkgs/development/python-modules/woob/default.nix
index 0887533adb9a..abc876b388a8 100644
--- a/pkgs/development/python-modules/woob/default.nix
+++ b/pkgs/development/python-modules/woob/default.nix
@@ -2,7 +2,7 @@
 , babel
 , buildPythonPackage
 , fetchFromGitLab
-, fetchpatch
+, pythonRelaxDepsHook
 , html2text
 , lxml
 , packaging
@@ -37,6 +37,11 @@ buildPythonPackage rec {
 
   nativeBuildInputs = [
     setuptools
+    pythonRelaxDepsHook
+  ];
+
+  pythonRelaxDeps = [
+    "packaging"
   ];
 
   propagatedBuildInputs = [
diff --git a/pkgs/development/tools/analysis/checkov/default.nix b/pkgs/development/tools/analysis/checkov/default.nix
index 555c7ddf4307..5a5f67f8b7ea 100644
--- a/pkgs/development/tools/analysis/checkov/default.nix
+++ b/pkgs/development/tools/analysis/checkov/default.nix
@@ -30,6 +30,7 @@ python3.pkgs.buildPythonApplication rec {
     "networkx"
     "openai"
     "packageurl-python"
+    "packaging"
     "pycep-parser"
     "termcolor"
   ];