diff --git a/pkgs/development/python-modules/scalene/default.nix b/pkgs/development/python-modules/scalene/default.nix
new file mode 100644
index 000000000000..29a51e38b631
--- /dev/null
+++ b/pkgs/development/python-modules/scalene/default.nix
@@ -0,0 +1,87 @@
+{ lib
+, buildPythonPackage
+, hypothesis
+, fetchpatch
+, fetchPypi
+, setuptools
+, setuptools-scm
+, cloudpickle
+, cython
+, jinja2
+, numpy
+, psutil
+, pynvml
+, pytestCheckHook
+, pythonOlder
+, rich
+}:
+
+buildPythonPackage rec {
+  pname = "scalene";
+  version = "1.5.38";
+  pyproject = true;
+  disabled = pythonOlder "3.9";
+
+  src = fetchPypi {
+    inherit pname version;
+    hash = "sha256-LR1evkn2m6FNBmJnUUJubesxIPeHG6RDgLFBHDuxe38=";
+  };
+
+  patches = [
+    # fix scalene_config import. remove on next update
+    (fetchpatch {
+      name = "scalene_config-import-fix.patch";
+      url = "https://github.com/plasma-umass/scalene/commit/cd437be11f600ac0925ce77efa516e6d83934200.patch";
+      hash = "sha256-YjFh+mu5jyIJYUQFhmGqLXhec6lgQAdj4tWxij3NkwU=";
+    })
+  ];
+
+  nativeBuildInputs = [
+    cython
+    setuptools
+    setuptools-scm
+  ];
+
+  propagatedBuildInputs = [
+    cloudpickle
+    jinja2
+    psutil
+    pynvml
+    rich
+  ];
+
+  __darwinAllowLocalNetworking = true;
+
+  nativeCheckInputs = [
+    pytestCheckHook
+  ];
+
+  checkInputs = [
+    hypothesis
+    numpy
+  ];
+
+  disabledTestPaths = [
+    # remove on next update
+    # Failing Darwin-specific tests that were subsequently removed from the source repo.
+    "tests/test_coverup_35.py"
+    "tests/test_coverup_42.py"
+    "tests/test_coverup_43.py"
+  ];
+
+  # remove scalene directory to prevent pytest import confusion
+  preCheck = ''
+    rm -rf scalene
+  '';
+
+  pythonImportsCheck = [ "scalene" ];
+
+  meta = with lib; {
+    description = "High-resolution, low-overhead CPU, GPU, and memory profiler for Python with AI-powered optimization suggestions";
+    homepage = "https://github.com/plasma-umass/scalene";
+    changelog = "https://github.com/plasma-umass/scalene/releases/tag/v${version}";
+    mainProgram = "scalene";
+    license = licenses.asl20;
+    maintainers = with maintainers; [ sarahec ];
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 30aced23bf3b..86e9e4bb074c 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -26823,6 +26823,8 @@ with pkgs;
 
   sampler = callPackage ../applications/misc/sampler { };
 
+  scalene = with python3Packages; toPythonApplication scalene;
+
   scalr-cli = callPackage ../tools/admin/scalr-cli { };
 
   scaphandre = callPackage ../servers/scaphandre { };
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index dc44a98191ce..e5fc2413189b 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -13299,6 +13299,8 @@ self: super: with self; {
 
   sasmodels = callPackage ../development/python-modules/sasmodels { };
 
+  scalene = callPackage ../development/python-modules/scalene { };
+
   scales = callPackage ../development/python-modules/scales { };
 
   scancode-toolkit = callPackage ../development/python-modules/scancode-toolkit { };