diff --git a/pkgs/applications/misc/retool/default.nix b/pkgs/applications/misc/retool/default.nix
index a88e719c6ddd..8d7811120979 100644
--- a/pkgs/applications/misc/retool/default.nix
+++ b/pkgs/applications/misc/retool/default.nix
@@ -19,17 +19,18 @@ python3.pkgs.buildPythonApplication {
     hash = "sha256-6y/7RR7O2xYKXdxaFtkRfnSlwygp/LRDUozUJo6ue7s=";
   };
 
-  patches = [
-    # pythonRelaxDepsHook will not work in this package until
-    # https://github.com/NixOS/nixpkgs/pull/248516 hits master
-    ./relax_deps.patch
-  ];
-
   nativeBuildInputs = with python3.pkgs; [
     poetry-core
+    pythonRelaxDepsHook
     qt6.wrapQtAppsHook
   ];
 
+  pythonRelaxDeps = true;
+
+  # ERROR: Could not find a version that satisfies the requirement PySide6 (from retool) (from versions: none)
+  # ERROR: No matching distribution found for PySide6
+  pythonRemoveDeps = [ "PySide6" ];
+
   buildInputs = [
     qt6.qtbase
   ] ++
diff --git a/pkgs/applications/misc/retool/relax_deps.patch b/pkgs/applications/misc/retool/relax_deps.patch
deleted file mode 100644
index 528d2b47d970..000000000000
--- a/pkgs/applications/misc/retool/relax_deps.patch
+++ /dev/null
@@ -1,25 +0,0 @@
-diff --git a/pyproject.toml b/pyproject.toml
-index 6e62347..34600a0 100644
---- a/pyproject.toml
-+++ b/pyproject.toml
-@@ -13,12 +13,14 @@ packages = [
- 
- [tool.poetry.dependencies]
- python = ">=3.10,<3.12"
--strictyaml = "^1.6.2"
--lxml = "^4.9.2"
--PySide6 = "^6.4.2"
--validators = "^0.20.0"
--alive-progress = "^3.0.1"
--psutil = "^5.9.4"
-+strictyaml = "*"
-+lxml = "*"
-+# ERROR: Could not find a version that satisfies the requirement PySide6 (from retool) (from versions: none)
-+# ERROR: No matching distribution found for PySide6
-+# PySide6 = "*"
-+validators = "*"
-+alive-progress = "*"
-+psutil = "*"
- 
- [tool.poetry.scripts]
- retool = "retool:main"