diff --git a/pkgs/applications/blockchains/polkadot/default.nix b/pkgs/applications/blockchains/polkadot/default.nix
index 0e71ddb7ba3b..9690ade2947c 100644
--- a/pkgs/applications/blockchains/polkadot/default.nix
+++ b/pkgs/applications/blockchains/polkadot/default.nix
@@ -92,5 +92,8 @@ rustPlatform.buildRustPackage rec {
     license = licenses.gpl3Only;
     maintainers = with maintainers; [ akru andresilva FlorianFranzen RaghavSood ];
     platforms = platforms.unix;
+    # See comment about wasm32-unknown-unknown in rustc.nix.
+    broken = lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+      !stdenv.hostPlatform.gcc.thumb or true;
   };
 }
diff --git a/pkgs/applications/misc/pagefind/default.nix b/pkgs/applications/misc/pagefind/default.nix
index 2da4e5eb7eb1..f72d999fc896 100644
--- a/pkgs/applications/misc/pagefind/default.nix
+++ b/pkgs/applications/misc/pagefind/default.nix
@@ -120,6 +120,9 @@ rustPlatform.buildRustPackage rec {
     license = licenses.mit;
     maintainers = with maintainers; [ pbsds ];
     platforms = platforms.unix;
+    # See comment about wasm32-unknown-unknown in rustc.nix.
+    broken = lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+      !stdenv.hostPlatform.gcc.thumb or true;
     mainProgram = "pagefind";
   };
 }
diff --git a/pkgs/by-name/re/rerun/package.nix b/pkgs/by-name/re/rerun/package.nix
index 4d9c8da8041c..6fedb10cfed1 100644
--- a/pkgs/by-name/re/rerun/package.nix
+++ b/pkgs/by-name/re/rerun/package.nix
@@ -126,5 +126,8 @@ rustPlatform.buildRustPackage rec {
     ];
     maintainers = with maintainers; [ SomeoneSerge ];
     mainProgram = "rerun";
+    # See comment about wasm32-unknown-unknown in rustc.nix.
+    broken = lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+      !stdenv.hostPlatform.gcc.thumb or true;
   };
 }
diff --git a/pkgs/by-name/su/surrealist/package.nix b/pkgs/by-name/su/surrealist/package.nix
index efd1773dee2f..3463c7ef3b2e 100644
--- a/pkgs/by-name/su/surrealist/package.nix
+++ b/pkgs/by-name/su/surrealist/package.nix
@@ -192,5 +192,8 @@ in stdenv.mkDerivation (finalAttrs: {
     mainProgram = "surrealist";
     maintainers = with maintainers; [ frankp ];
     platforms = platforms.linux;
+    # See comment about wasm32-unknown-unknown in rustc.nix.
+    broken = lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+      !stdenv.hostPlatform.gcc.thumb or true;
   };
 })
diff --git a/pkgs/by-name/te/tetrio-desktop/tetrio-plus.nix b/pkgs/by-name/te/tetrio-desktop/tetrio-plus.nix
index 43102d6c8a26..832123b61c15 100644
--- a/pkgs/by-name/te/tetrio-desktop/tetrio-plus.nix
+++ b/pkgs/by-name/te/tetrio-desktop/tetrio-plus.nix
@@ -78,6 +78,9 @@ let
       license = lib.licenses.mit;
       maintainers = with lib.maintainers; [ huantian wackbyte ];
       platforms = lib.platforms.linux;
+      # See comment about wasm32-unknown-unknown in rustc.nix.
+      broken = lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+        !stdenv.hostPlatform.gcc.thumb or true;
     };
   };
 
diff --git a/pkgs/development/compilers/rust/rustc.nix b/pkgs/development/compilers/rust/rustc.nix
index ccaf681307e7..da458211550f 100644
--- a/pkgs/development/compilers/rust/rustc.nix
+++ b/pkgs/development/compilers/rust/rustc.nix
@@ -103,7 +103,9 @@ in stdenv.mkDerivation (finalAttrs: {
       stdenv.targetPlatform.rust.rustcTargetSpec
 
     # Other targets that don't need any extra dependencies to build.
-    ] ++ optionals (!fastCross) [
+    # Temporarily broken if some global compiler flags are set:
+    # https://github.com/NixOS/nixpkgs/pull/317273
+    ] ++ optionals (!fastCross && !lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] && stdenv.hostPlatform.gcc.thumb or true) [
       "wasm32-unknown-unknown"
 
     # (build!=target): When cross-building a compiler we need to add
diff --git a/pkgs/servers/ldap/lldap/default.nix b/pkgs/servers/ldap/lldap/default.nix
index 5a0444235967..28f05322c77c 100644
--- a/pkgs/servers/ldap/lldap/default.nix
+++ b/pkgs/servers/ldap/lldap/default.nix
@@ -84,6 +84,9 @@ in rustPlatform.buildRustPackage (commonDerivationAttrs // {
     changelog = "https://github.com/lldap/lldap/blob/v${lldap.version}/CHANGELOG.md";
     license = licenses.gpl3Only;
     platforms = platforms.linux;
+    # See comment about wasm32-unknown-unknown in rustc.nix.
+    broken = lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+      !stdenv.hostPlatform.gcc.thumb or true;
     maintainers = with maintainers; [ bendlas ];
     mainProgram = "lldap";
   };
diff --git a/pkgs/servers/teleport/generic.nix b/pkgs/servers/teleport/generic.nix
index 84b57160d4fa..94ca520964cd 100644
--- a/pkgs/servers/teleport/generic.nix
+++ b/pkgs/servers/teleport/generic.nix
@@ -180,6 +180,9 @@ buildGoModule rec {
     platforms = platforms.unix;
     # go-libfido2 is broken on platforms with less than 64-bit because it defines an array
     # which occupies more than 31 bits of address space.
-    broken = stdenv.hostPlatform.parsed.cpu.bits < 64;
+    broken = stdenv.hostPlatform.parsed.cpu.bits < 64 ||
+      # See comment about wasm32-unknown-unknown in rustc.nix.
+      lib.any (a: lib.hasAttr a stdenv.hostPlatform.gcc) [ "cpu" "float-abi" "fpu" ] ||
+      !stdenv.hostPlatform.gcc.thumb or true;
   };
 }