diff --git a/pkgs/build-support/setup-hooks/fix-darwin-dylib-names.sh b/pkgs/build-support/setup-hooks/fix-darwin-dylib-names.sh
index af2ff0cc9662..55e196e654df 100644
--- a/pkgs/build-support/setup-hooks/fix-darwin-dylib-names.sh
+++ b/pkgs/build-support/setup-hooks/fix-darwin-dylib-names.sh
@@ -23,7 +23,7 @@ fixDarwinDylibNames() {
     for fn in "$@"; do
         if [ -L "$fn" ]; then continue; fi
         echo "$fn: fixing dylib"
-        int_out=$(install_name_tool -id "$fn" "${flags[@]}" "$fn" 2>&1)
+        int_out=$(@targetPrefix@install_name_tool -id "$fn" "${flags[@]}" "$fn" 2>&1)
         result=$?
         if [ "$result" -ne 0 ] &&
             ! grep "shared library stub file and can't be changed" <<< "$out"
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 08f94a54a587..07aba73d0fcf 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -641,7 +641,9 @@ in
 
   setJavaClassPath = makeSetupHook { } ../build-support/setup-hooks/set-java-classpath.sh;
 
-  fixDarwinDylibNames = makeSetupHook { } ../build-support/setup-hooks/fix-darwin-dylib-names.sh;
+  fixDarwinDylibNames = makeSetupHook {
+    substitutions = { inherit (binutils) targetPrefix; };
+  } ../build-support/setup-hooks/fix-darwin-dylib-names.sh;
 
   keepBuildTree = makeSetupHook { } ../build-support/setup-hooks/keep-build-tree.sh;