diff --git a/pkgs/development/python-modules/islpy/default.nix b/pkgs/development/python-modules/islpy/default.nix
index ca84beae2eef..83f0b26c0047 100644
--- a/pkgs/development/python-modules/islpy/default.nix
+++ b/pkgs/development/python-modules/islpy/default.nix
@@ -1,41 +1,71 @@
-{ lib
-, buildPythonPackage
-, fetchPypi
-, isl
-, pybind11
-, pytestCheckHook
-, pythonOlder
-, six
+{
+  lib,
+  buildPythonPackage,
+  fetchFromGitHub,
+  pythonOlder,
+
+  setuptools,
+  cmake,
+  nanobind,
+  ninja,
+  pcpp,
+  scikit-build,
+  isl,
+
+  pytestCheckHook,
 }:
 
 buildPythonPackage rec {
   pname = "islpy";
   version = "2023.2.5";
-  format = "setuptools";
+  pyproject = true;
 
-  disabled = pythonOlder "3.6";
+  disabled = pythonOlder "3.8";
 
-  src = fetchPypi {
-    inherit pname version;
-    sha256 = "sha256-3XQ5i682k4q7fCqdmCjMGi5UnGyASFzsiwaymr+q0Y8=";
+  src = fetchFromGitHub {
+    owner = "inducer";
+    repo = "islpy";
+    rev = "v${version}";
+    hash = "sha256-0m41G5HlPrgt4rDY3Y9cKBJGHSnLg/R+IywBO1anRpQ=";
   };
 
-  postConfigure = ''
-    substituteInPlace setup.py \
-      --replace "\"pytest>=2\"," ""
+  postPatch = ''
+    substituteInPlace pyproject.toml \
+        --replace-fail "setuptools>=42,<64;python_version<'3.12'" "setuptools>=42"
   '';
 
-  buildInputs = [ isl pybind11 ];
-  propagatedBuildInputs = [ six ];
+  build-system = [
+    setuptools
+    cmake
+    nanobind
+    ninja
+    pcpp
+    scikit-build
+  ];
+
+  buildInputs = [ isl ];
+
+  dontUseCmakeConfigure = true;
+
+  preConfigure = ''
+    python ./configure.py \
+        --no-use-shipped-isl \
+        --isl-inc-dir=${lib.getDev isl}/include \
+  '';
+
+  # Force resolving the package from $out to make generated ext files usable by tests
+  preCheck = ''
+    mv islpy islpy.hidden
+  '';
 
-  preCheck = "mv islpy islpy.hidden";
   nativeCheckInputs = [ pytestCheckHook ];
+
   pythonImportsCheck = [ "islpy" ];
 
-  meta = with lib; {
+  meta = {
     description = "Python wrapper around isl, an integer set library";
     homepage = "https://github.com/inducer/islpy";
-    license = licenses.mit;
-    maintainers = [ ];
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ tomasajt ];
   };
 }
diff --git a/pkgs/development/python-modules/loopy/default.nix b/pkgs/development/python-modules/loopy/default.nix
index 995c99e100ec..488d055b7213 100644
--- a/pkgs/development/python-modules/loopy/default.nix
+++ b/pkgs/development/python-modules/loopy/default.nix
@@ -1,39 +1,47 @@
-{ lib
-, buildPythonPackage
-, codepy
-, cgen
-, colorama
-, fetchFromGitHub
-, genpy
-, islpy
-, mako
-, numpy
-, pymbolic
-, pyopencl
-, pyrsistent
-, pythonOlder
-, pytools
+{
+  lib,
+  buildPythonPackage,
+  codepy,
+  cgen,
+  colorama,
+  fetchFromGitHub,
+  genpy,
+  immutables,
+  islpy,
+  mako,
+  numpy,
+  pymbolic,
+  pyopencl,
+  pyrsistent,
+  pythonOlder,
+  pytools,
+  setuptools,
+  typing-extensions,
 }:
 
 buildPythonPackage rec {
   pname = "loopy";
   version = "2024.1";
-  format = "setuptools";
+  pyproject = true;
 
-  disabled = pythonOlder "3.7";
+  disabled = pythonOlder "3.8";
 
   src = fetchFromGitHub {
     owner = "inducer";
-    repo = pname;
+    repo = "loopy";
     rev = "refs/tags/v${version}";
-    hash = "sha256-R0Wry4r8Y7VKqsyrZ3odEOUy4T9di9rFQzq7BD0LG58=";
+    hash = "sha256-mU8vXEPR88QpJpzXZlZdDhMtlwIx5YpeYhXU8Vw2T9g=";
+    fetchSubmodules = true; # submodule at `loopy/target/c/compyte`
   };
 
-  propagatedBuildInputs = [
+  build-system = [ setuptools ];
+
+  dependencies = [
     codepy
     cgen
     colorama
     genpy
+    immutables
     islpy
     mako
     numpy
@@ -41,15 +49,22 @@ buildPythonPackage rec {
     pyopencl
     pyrsistent
     pytools
+    typing-extensions
   ];
 
+  postConfigure = ''
+    export HOME=$(mktemp -d)
+  '';
+
+  pythonImportsCheck = [ "loopy" ];
+
   # pyopencl._cl.LogicError: clGetPlatformIDs failed: PLATFORM_NOT_FOUND_KHR
   doCheck = false;
 
-  meta = with lib; {
+  meta = {
     description = "A code generator for array-based code on CPUs and GPUs";
     homepage = "https://github.com/inducer/loopy";
-    license = licenses.mit;
-    maintainers = with maintainers; [ ];
+    license = lib.licenses.mit;
+    maintainers = with lib.maintainers; [ tomasajt ];
   };
 }
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index b2b19b976c0a..edb54973535d 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -5917,7 +5917,9 @@ self: super: with self; {
 
   isbnlib = callPackage ../development/python-modules/isbnlib { };
 
-  islpy = callPackage ../development/python-modules/islpy { };
+  islpy = callPackage ../development/python-modules/islpy {
+    isl = pkgs.isl_0_24;
+  };
 
   iso3166 = callPackage ../development/python-modules/iso3166 { };