nixpkgs/nixos/doc/manual/configuration/profiles/perlless.section.md

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Perlless

::: {.warning} If you enable this profile, you will NOT be able to switch to a new configuration and thus you will not be able to rebuild your system with nixos-rebuild! :::

Render your system completely perlless (i.e. without the perl interpreter). This includes a mechanism so that your build fails if it contains a Nix store path that references the string "perl".